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Sermorelin stimulates pituitary GH release, deepening slowwave (NREM) sleep but may modestly suppress REM, whereas Ipamorelin produces a more balanced increase in both deep and REM phases with fewer cortisol spikes

Reports of Vinnytsia National Medical University 27 (4): 66977

doi: Hu, Y., Zheng, S.-L., Ye, X.-L., Shi, J.-N., Zheng, X.-W., Pan, H.-S., Zhang, Y.-W., Yang, X.-L

Two-thirds of reviewers who reported weight loss, suppressed appetite or food cravings disappearing gave the medication high marks, even if they were out of commission

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