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These medications work by mimicking the action of endogenous GLP-1, binding to GLP-1 receptors found throughout the body, particularly in the pancreas, brain, and gastrointestinal tract

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Rats and mice developed C-cell tumors when given GLP-1 medications at high doses over extended periods

While some individuals may see weight loss within the first few weeks of treatment, optimal results are typically observed over a longer duration, from six months to a year

12,13,14,15,16 The agents newly approved in the 21st century for PCa treatment and diagnosis are summarized in Table 1

Tissue sections were observed under a Leica DMI-3000B microscope (Leica, Germany)