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In addition to the colocalization of Fas with raft markers, the researchers also detected the presence of FasL, FADD, and activated caspase-8, further supporting the formation of a functional DISC in aged RBCs

To further validate these results, we analysed a subset of genes from the Met deprivation signature, which were among the most highly enriched by GSEA, in reprogramming tissues by quantitative PCR with reverse transcription (RTqPCR)