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DAutreaux B, Toledano MB

66 (Tables 1 and 2) Current GLP-1RAs GLP-1RAs are synthetic protein preparations that have partial or complete amino acid sequence homology with GLP-1 found in the body, are not easily degraded, have longer half-lives and have stronger biological activity

Mechanism of Action Blocks angiotensin II type 1 (AT1) receptors Prevents vasoconstriction and aldosterone secretion Results in lower blood pressure and reduced cardiac workload Unlike ACE inhibitors, it does not cause cough (less bradykinin effect) 2

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