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A few other genetic risk factors shed light on the pathogenesis of SJS/TENpolymorphisms in cytochrome P450 and other genes required for drug metabolism, and polymorphisms in the antigen presentation pathway

Oral glutathione has very limited bioavailability and cannot reliably achieve therapeutic plasma concentrations

doi:10.2174/0929867328666210324161205

Individuals with moderate to severe TBI often experience persistent neurocognitive deficits, including short-term memory loss, executive dysfunction, and slowed cognitive processing for which there are currently no FDA-approved treatments

We summarize mechanistic insights across cellular and molecular domains, critically appraise preclinical and clinical findings, and discuss translational challenges that include bioavailability and brain penetration, study heterogeneity, biomarker guided stratification, and pediatric safety

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