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However, the most important key for successful treatment would be the presence of optimally activated T cells in tumor microenvironment with controlled ROS activity which may represent fruitful ground for long-term molecular anticancer strategies
FIGURE 5 4 Discussion Current research on the pathogenesis of T2D increasingly focuses on the gut-islet axis, where gut microbiota-derived SCFAs ( This study is the first to systematically demonstrate that the botanical extract LEO ameliorates T2D metabolic disorder via a cascade mechanism: restructuring gut microbiota composition, restoring SCFA-producing bacterial populations, elevating colonic butyrate levels, activating MPC2 expression, and ultimately repairing mitochondrial energy metabolism in enteroendocrine cells to enhance GLP-1 secretion
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Because body composition changes are ultimately driven by sustained energy balance, the durability of appetite suppression becomes a major factor in long-term outcomes
ER stress in autoimmune diseases ER stress influences immune cell survival, activation, differentiation, and effector functions, and its dysregulation disrupts immune homeostasis, contributing to the development and progression of autoimmune diseases
S., Srinivasan, B
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