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Regulation of ferroptosis through diverse pathways The system Xc - / GSH/ GPX4 axis The System Xc - (the cystine/glutamate antiporter system) / Glutathione (GSH) / Glutathione Peroxidase 4 (GPX4) axis, characterized by elevated GSH and GPX4 expression, represents the canonical pathway of ferroptosis
L-Carnitine is an amino acid which assists with fatty acid metabolism and weight control
B12 converts homocysteine, an inflammatory amino acid, into methionine
developed supramolecular prodrug nanoassemblies (SPNA) for reactive nitrogen species (RNS)-enhanced chemotherapy (Figure 3D) (Figures 3E, F), thereby generating highly toxic peroxynitrite anion (ONOO )
Stated differently, FM loss occurred at a rate 2-3x higher than FFM loss
Diabetes 57 , 13491354 (2008)
