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Moreover the hormonal rearrangement intrinsic of pregnancy [17] redistributes the interrelationships of metabolic pathways that sustain fetus growth and differentiation, particularly in rats, that have a short pregnancy (about 17 d)

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3 Adverse events in PIONEER 2 1,3 Comparator AE rates are not an adequate basis for comparison of safety between products 1 Because clinical trials are conducted under widely varying conditions, AE rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice 1 AE=adverse event

Australian and New Zealand journal of medicine

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Local Reactions Implant or Injection Site Reactions: Pain, redness, bruising, swelling, or itching at the site where the implant or injection was placed