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doi: 10.1016/j.it.2018.04.002 4 AlmoiliqyM.WenJ.XuB.SunY

This minimizes interaction but doesn't eliminate it entirely

Nevertheless, his case is sometimes cited as an example of vitamin B12 deficiency and how severe it can get with time, if left untreated, it can lead to serious health issues, including neurological symptoms like dementia

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The reaction was preincubated for 15 min

While some researchers experiment with extended dosing intervals, the pharmacokinetics suggest that every-two-week dosing would produce significant troughs where drug levels fall below therapeutic thresholds