The peptide was studied in an osteoporosis-mimicking model (glucocorticoid-induced bone loss in adult rats), where it enhanced bone formation (PMID: 11735244)
In addition, exenatide was shown to activate GLP-1R and inhibit the PI3K/AKT pathway to inhibit the growth, migration, and invasion of ovarian cancer cells, and promote cell apoptosis, thereby producing anticancer effects on diabetic patients with ovarian cancer (218)
Tlr4/nf-Kb signaling induces gsdmd-related pyroptosis in tubular cells in diabetic kidney disease
Dec 2010;69(6):565-71
Patients with a personal history of any cancer, even if treated and clear, get a longer conversation and often a clearance from oncology before we proceed
Ozempic, Wegovy, Mounjaro, and Zepbound are not FDA-approved specifically for arthritis or autoimmune disease