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Heres a quick look at some main tips for managing GLP-1 fatigue: Eat balanced, nutrient-rich meals Prioritize protein and essential vitamins Stay hydrated and support electrolytes Pace activity and protect sleep Adjust doses slowly with your provider Track symptoms and energy patterns Get labs if fatigue persists If your tiredness feels extreme or long-lasting, loop in your healthcare team before making big changes

But the trial does have one huge limitation, says Powell-Wiley: 84 percent of the studys participants were white and 72 percent were men