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While lifestyle interventions remain effective in delaying or preventing T2D onset among people with prediabetes, long-term adherence poses considerable challenges
Signs of infection Infection at an injection site is uncommon when proper aseptic technique is used, but it does occur
Obesity The FDA considers patients with a BMI of 30 or higher as eligible for GLP-1 medications for weight loss
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Published online September 30, 2025
Intriguingly, acute colonic propionate delivery decreases food intake and stimulates the secretion of PYY and GLP-1, while long-term colonic propionate delivery has little effects on PYY and GLP-1 release in humans [74], which may be associated with propionate resistance
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