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Where it works: Liver: Increases hepatic glucose production and fat oxidation (when carbs are low) Adipose tissue: Stimulates lipolysis (breakdown of stored fat into free fatty acids) Brown adipose tissue: Activates thermogenesis (heat production from burning fat) Muscle: May increase fat oxidation during exercise Weight loss contribution: The glucagon component appears to add an additional 2-3% weight loss beyond the GLP-1/GIP combination (24% vs 22% for tirzepatide)
Professor Anthony Heagerty has received lecture honoraria from Servier
Here is how to think about optimizing for specific non-weight-loss outcomes
2017;136(20):e348-e392
A new rash at or near an injection site could be a simple local reaction, but it could also represent a lupus skin flare triggered by tissue trauma (the pathergy phenomenon)
While Novo Nordisk provides warning labels about common side effects of Wegovy and their other semaglutide medications, their labels may not provide adequate warning about severe health risks such as stomach paralysis, intestinal blockages, or bowel obstruction
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