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Semaglutide patents are expiring in several large ex-US markets, enabling cheap generics that could cannibalize Ozempic and Wegovy over time and pressure gross margins further
Inositols help improve insulin sensitivity, but may not be effective for all
Patients on long-term corticosteroids may experience unpredictable appetite patterns, making it harder to gauge whether tirzepatide is working or whether steroid-driven hunger is overriding the medication's satiety effects
Canagliflozin, a sodium glucose cotransporter 2 inhibitor, attenuates obesity-induced inflammation in the nodose ganglion, hypothalamus, and skeletal muscle of mice
Eric Topol (05:36): Well, also just to set the foundation here, which you alluded to, there had been so many attempts to come up with a drug that would work, not just of course in diabetes where there are many classes of drugs, but moreover, to treat the condition of obesity
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