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Mounjaro is a dual agonist , meaning it activates two receptors: GLP1 receptor GIP receptor The UK SmPC also lays out how dosing usually works (start low and increase slowly): starting dose 2.5 mg once weekly, then move to 5 mg, then step up in 2.5 mg increments if needed (with at least 4 weeks at each step)
Clinical check-ins and symptom logs allowed clinicians to slow escalation rather than stop therapy, preserving continuity and reducing avoidable discontinuations
The peptide incorporates specific amino acid substitutions at key positions to enhance stability against enzymatic degradation while preserving high affinity for the GHRH receptor
