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Being a GLP-1 analog, sema is a modified peptide that includes specific substitutions and a fatty acid side chain, which enhances its binding to albumin and significantly extends its half-life

To investigate leads impact on immune functions, we stimulated blood, spleen and lymph node immune cells from control and lead-treated mice with Cell Stimulation Cocktail (PMA/ionomycin) for 4 h before CyTOF examination

Intriguingly, beyond their metabolic benefits, GLP-1RAs also exhibit anti-inflammatory effects

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Diabetes 47 (2), 159169