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At least two kinds of glucose sensor neurons have been described in the brain: glucose-excited neurons are located mainly in the VMH and are excited by increased glucose levels in the extracellular space, while glucose-inhibited neurons (mainly present in the LH) are excited by decreases in glucose concentrations
However, the number of studies is limited, and high-quality research in humans is needed
This study demonstrated the importance of combined GLP-1R and GCGR signalling, as administration of the balanced co-agonist to Glp1r -/- mice led to hyperglycaemia, further demonstrating the necessity of GLP-1R and GCGR co-agonism to minimise this predicted side-effect
Surprisingly, despite consistent and large increases in different muscle groups with BA supplementation, evidence suggests actual incorporation of BA into muscle carnosine is low
What I worry about is not simply whether the scale is moving
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