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Mechanism of the inhibitory effect of zwitterionic drugs (levofloxacin and grepafloxacin) on carnitine transporter (OCTN2) in Caco-2 cells
The patient base is also expanding beyond adults, with clinical use increasing in adolescent obesity management following expanded pediatric guidance
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[6] Pharmacodynamic synergy with other carbonic-anhydrase inhibitors (acetazolamide, zonisamide) amplifies the risk of metabolic acidosis and nephrolithiasis, while combined use with valproate has been repeatedly implicated in hyperammonemic encephalopathy even at therapeutic serum valproate levels
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