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Observational studies show a reduced risk of AD in people taking these drugs for diabetes or obesity, and two small clinical trials showed promise but were not conclusive

Food and Drug Administration (FDA) for improving glycemic control among adults with type 2 diabetes

10.1046/j.1525-1373.2000.22349.x Proc

These studies have laid a solid basis for the clinical application of GLP-1R agonists for treating DPN

For example, one study showed that in people with type 2 diabetes, treatment with semaglutide (1 mg weekly) causes an average loss of about 6% of body weight over 40 weeks, while treatment with tirzepatide (15 mg/week) leads to an 11% weight loss in this population

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