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32,33 Also, mounting evidence suggests that these different processes and enzymes have functional connections for NADPH homeostasis in cancer
C32 is the second active-site cysteinyl residue of PfGrx and C88 is the third cysteinyl residue, which is in the proximity of the active site and can also undergo redox modifications 14,26,30
These findings were shared at a major medical conference (EASD) in September 2025
Bottom line: Among all the peptides we work with, GHK-Cu has one of the mildest side effect profiles
And actually I think I was a co-author of that study of that study you're referring to, if it's the one by Tom Sedlak and Akira Sawa and others
Closure of the flexible loop excludes solvent water from the active site and provides K103 which is essential for catalysis (Ozturk et al., 1995)
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