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Special attention is given to the translational potential of microbiome-based approaches, including dietary modification, psychobiotics, and FMT, to prevent or mitigate CNS disorders
As a study stated, The cells of the adult human brain consume approximately 20% of the oxygen utilized by the body although the brain comprises only 2% of the body weight. With this high oxygen consumption, the brain is extremely susceptible to ROS, which antioxidants like Glutathione must balance to prevent cell damage
Notably, the ongoing phase I/II trial of XNW5004, an EZH2 inhibitor, in combination with pembrolizumab (NCT06022757) exemplifies the effort to reprogram epigenetic states and restore ICB sensitivity in solid tumors resistant to conventional treatments
Gold LT, Masson GR
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