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Burt, 2011.) Improved cognitive function in healthy adults and GH-deficient subjects
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Commercial translation of this technology is exemplified by PureTech Health (founded 2001), which leverages MEVs within its preclinical Discovery platform for oral delivery of biologics (e.g., antisense oligonucleotides) and complex small molecules targeting rheumatoid arthritis, diabetes, autoimmune disorders, and oncology (Munagala et al., 2016
Researchers can pharmacologically dissect these pathways using LY294002 (PI3K inhibitor) or U0126 (MEK inhibitor) to determine which downstream arm mediates a specific IGF-1 LR3 effect in their experimental system
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