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The Safety: It is generally safe and protects organs, unlike many harsh drugs
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In summary, regulating the metabolic reprogramming of macrophages has become an emerging and effective direction for RA treatment
Postulated mechanisms of metformin action, including AMPK activation and complex I inhibition, have been demonstrated in the setting of a consistent pleiotropic activity of this drug, suggesting that several molecular targets could be involved ( 3.2.1.2 Clinical studies Based on the mechanisms described so far, the repurposed use of metformin in NBD may offer promising opportunities
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