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Pipeline (Phase 3 trials completed, FDA decision pending as of April 2026): Survodutide (BI 456906): Dual GLP-1/glucagon agonist from Boehringer Ingelheim

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Although some progress has been made in understanding the biological functions and potential mechanisms of the carnitine metabolism pool, their complexity and differences in pharmacology and pathophysiology still need to be further explored and understood

however, during oxidative stress, Nrf2 dissociates from Keap1 and translocates to the nucleus where it binds to antioxidant response elements