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The study also found that adults taking a GLP-1 had an increased risk for interstitial nephritis, a type of kidney condition that Al-Aly says is almost like an allergic reaction that the kidney mounts against certain drugs. He says more long-term studies are needed to better understand the risks and benefits of prolonged use

Glucagon-Like Peptide-1 Receptor Agonists and Risk for Gastroesophageal Reflux Disease in Patients With Type 2 Diabetes : A Population-Based Cohort Study

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One of the earliest developed DPP-4 inhibitors was valine-pyrrolidide which functioned as a prototype for DPP-4 inhibition in early proof-of-concept experimental studies