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GLP-1 agonists are typically prescribed to adults over the age of 18 who are overweight or obese with a body mass index (BMI) above 30
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The consensus statement does suggest, however, that DPP-4 inhibitors may be appropriate in select populations based on concerns associated with weight gain and hypoglycemia, similar to the AACE and ACE recommendations
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The same gastrointestinal side effects, central adaptations, and pleiotropic actions that once discouraged development are now recognized as manageable features of peptide pharmacology when appropriately contextualized
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