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Das Tripeptid wurde bereits 1921 entdeckt und bekam eine Erstbeschreibung, wobei der Kenntnisstand mit allen weiteren Untersuchungen erweitert wurde

Cellular mechanisms of Decreased Response Desensitization Downregulation Tachyphylaxis Tolerance Desensitization Desensitization refers to a reduced response to an agonist drug due to over activation of a receptor (high doses, prolonged exposure to agonist)