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RNA sequencing and pathway enrichment analysis show FOXO4-DRI significantly downregulates extracellular matrix-receptor interaction pathways, including fibronectin (Fn1), tenascin C (Tnc), and thrombospondin 2 (Thbs2), all critical components of fibrotic tissue architecture

For deeper regenerative benefits, such as tendon or gut lining repair, results typically accumulate over 4 to 8 weeks of consistent therapy

Drug Delivery Translational Research 9, 625630

10.1016/j.mce.2008.11.015 112 VangaS

10.1007/s11064-020-02978-4 144 YaglovaN

Adults aged 40-60 face highest risk, with women 4 times more likely to develop the condition, and diabetics showing 10-20% prevalence compared to 2-5% in the general population