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Common gastrointestinal effects (Phase 2 NEJM) Retatrutide GI side effects at 12 mg in the Phase 2 NEJM trial Effect Nausea Rate at 12 mg Up to 25% Effect Diarrhea Rate at 12 mg Up to 23% Effect Vomiting Rate at 12 mg Up to 26% Effect Constipation Rate at 12 mg Up to 16% GI symptoms were most common during dose escalation and were usually mild to moderate

DHEA (100 mg/day) Supports androgen recovery, mood, and libido as natural hormone levels normalize post-cycle

Research suggests that the peptide may help improve the function of joints, particularly in cases where cartilage damage has occurred

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Tolonen M, Palva JM, Andersson S, Vanhatalo S (2007) Development of the spontaneous activity transients and ongoing cortical activity in human preterm babies

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