These medications: reduce appetite lower inflammation improve liver fat improve metabolic markers reduce cardiovascular events (SELECT trial) They do not : build muscle increase VO max improve mitochondrial function replace strength training fix metabolic flexibility guarantee long-term weight maintenance 2
These are not dietary supplements, they are not approved drugs, they are chemicals with no good manufacturing practices (GMP) or quality control testing requirements for identity or contaminants as is required for supplements
They are a support tool, not a replacement for lifestyle habits
Marketing that focuses mainly on buzzwords, celebrity endorsements, or promises of effortless weight loss should be approached with caution
Importantly, DSIP did not alter the rate of uncoupled respiration (VDNP), which is the oxygen consumption rate when the proton gradient is dissipated
These medications target key pathways involved in appetite regulation, glucose metabolism, and energy expenditure, offering a multifaceted approach to combating obesity and related metabolic disorders