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The absence of blend-level human data is not a technicality to route around it is the central fact about KLOWs status

The investigators identified 64,000+ adults aged 45 or older with overweight or obesity and atherosclerotic cardiovascular disease (prior heart attack, stroke, or peripheral artery disease) but no diabetes diagnosis, who initiated semaglutide or tirzepatide between May 2022 and January 2025

Increase dose : If 4 weeks at same dose with no loss, increase to next level

In many cases, its not about eating too much

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While evidence suggests central mediation, possibly through dopamine signaling, the precise neurocircuit-level mechanisms are yet to be fully elucidated