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Nature (2012) 489:2429
Phase 3 clinical trials testing GLP-1 RAs for weight management have demonstrated mean weight reduction of 8% to 15%, with 63% to 86% of patients achieving a 5% or greater reduction in body weight, and 33% to 69% achieving a 10% or greater reduction after 13 to 17 months of use
It means different
It can be argued that significant effects were seen largely due to the homogeneous participant pool that started out with decreased metabolic health, and that results may not apply to healthy weight individuals
That is a five-day gap (well above 48 hours)
This highlights the role of 1,25(OH)2D in controlling osteosarcoma cell creation through mitochondrial and redox balance regulation (138)
