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This activation leads to increased intracellular cyclic AMP (cAMP) levels through adenylyl cyclase stimulation

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The review also noted that decreased GLP-1 secretion may contribute to obesity development, and that exaggerated secretion may be responsible for postprandial reactive hypoglycaemia

Also toxicity of water soluble vitamins is much less common than toxicity for fat soluble vitamins, because excess water soluble vitamins dont easily build up in the body

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Furthermore, non-pharmacological methods, such as ice packs, compression garments, and physical therapy, can complement pharmacological interventions