Although xCT inhibition as a regulator of ferroptosis is a potential strategy for cancer therapy, the potential targets of ferroptosis in the treatment of ovarian cancer in vivo and their mechanisms remain poorly understood
Cholesterol efflux has long been regarded as a critical mechanism of maintaining intracellular cholesterol homeostasis, which could be primarily regulated by the LXR transcription factors and their targeted genes, the ATP-binding cassette (ABC) cholesterol transporters ABCA1 and ABCG1 (Robichaud and Ouimet, 2019)
Through this process, tumor cells exhibit higher migratory and invasive ability, poorer outcomes, and increased resistance to various treatments (Li et al., 2015)
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REFERENCES: Usategui-Martn, Ricardo et al
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