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To test if MOTS-c can improve physical performance in mice that have been on a HFD, we fed young C57BL/6J mice a HFD, or a normal diet, for 2 weeks before initiating daily MOTS-c injections (15 mg/kg/day) for 2 weeks prior to a treadmill running test (Supplementary Fig

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In addition, we did not observe increased deposition of GAG from FOXO4-DRI pre-treated PDL9 chondrocytes (Figure 3C)