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An enzyme called tyrosinase is needed to create melanin (the pigment that causes the brown spots) and while several other skin lightening agents work to inhibit the synthesis of tyrosinase itself (like vitamin C or licorice), arbutin lets tyrosinase be and rather hinders the melanin-forming activity of the enzyme

Immune and Cellular Support Boosts immune defense and helps protect against environmental pollutants and stress May support energy levels by improving mitochondrial function Why IM

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Chest 158 , e9e13 (2020)

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95%CI = 1.363.22), amitriptyline (RR = 2.12