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Altered intestinal permeability (leaky gut) allows the passage of food antigens, toxins, bacteria, and microbial products, promoting inflammation and dysregulated immune responses, triggering autoimmunity through various mechanisms [188]

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The researchers documented severe T-cell hyperproliferation and pronounced mitochondrial lipid oxidative damage, concluding that oxidative stress is a shared mechanistic basis for the debilitating fatigue seen in both conditions