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These changes may be reversible when stress is alleviated, or they may lead to permanent alterations in development if the stress is prolonged

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4.3.2.2 TMAO drives chondrocyte ferroptosis in OA progression Trimethylamine (TMA), produced by intestinal microbiota metabolism of linoleic acid, glycerophosphocholine, and choline, is subsequently oxidized in the liver to yield TMAO

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