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Our previous transcriptomic profiling further linked shunt responsiveness to gene programs involved in mitochondrial function and proteostasis 40

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prausnitzii , Veillonella parvula , Megasphaera elsdenii , Dialister succinatiphilus , Acidaminococcus intestini , Faecalicoccus pleomorphus , and Subdoligranulum var iabile ) while 8 species were specific to particular CKD stages (Increased level of Megasphaera micronuciformis in the mild CKD group, decreased expression of Alistipes indistinctus , Alistipes inops , and Bacteroides uniformis in the moderate CKD group, and increased abundance of the Turicibacter sanguinis with a concomitant reduction in the levels of Streptococcus mutans , Bifidobacterium adolescentis , and Lactobacillus crispatus in the ESKD group)