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Obesity increases the risk to develop type 2 diabetes mellitus, cardiovascular diseases, hypertension, fatty liver disease, sleep apnea, osteoarthritis, dyslipidemia, certain types of cancer, disruption of endocrine circuits, and low-grade systemic inflammation [1]

In the STEP 1 trial, participants lost an average of 15% of starting body weight over 68 weeks

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Some preclinical IGF-1 work suggests that local IGF-1 expression can affect muscle hypertrophy and regeneration in animal models 12

Interleukin-2 (IL-2) Interleukin-2 (IL-2) is another type of immunotherapy that helps strengthen the immune system so it can better fight cancer

doi: 10.1016/j.bbrc.2017.06.075 170 ZarateA.Manuel-ApolinarL.BasurtoL.De la ChesnayeE.SaldivarI