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Acknowledgements This work was supported by the National Natural Science Foundation of China (82272660, 82160456, and 81972399), the Guizhou Provincial Science and Technology Projects (ZK[2022]394), the Excellent Young Talents Plan of Guizhou Medical University ([2020]47), the Natural Science Foundation Research Team of Guangdong Province (2018B030312001), the Plan on Enhancing Scientific Research in GMU (02-410-2302289XM), the Basic and Applied Basic Research Project of the Guangzhou Basic Research Program (202201011411)