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TLR4 gene ablation in a transgenic mouse model of MSA with oligodendroglial -syn overexpression impaired the phagocytic ability of microglia to -syn, leading to enhanced motor impairment and augmented loss of nigrostriatal dopaminergic neurons

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For example, homologues with CxxS- and CxxC-motifs at the active site are classified as monothiol and dithiol glutaredoxins, respectively

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Its reassuring to see robust evidence showing that GLP-1RAs are not associated with clinically significant bone loss and may even have a protective effect on bone health