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Animal LD50 studies in mice showed approximately 320 mg per kilogram of body weight, which translates to roughly 22,400 mg for a 154-pound human
no signal of pancreatitis, severe hypoglycemia, or thyroid C-cell pathology has emerged [PubMed]
Women of childbearing age should use reliable contraception while on semaglutide and stop the medication at least two months before trying to conceive
These trials followed patients receiving GLP-1 agents for several years while closely monitoring adverse events
Orforglipron is an experimental GLP-1 oral drug, and Eli Lilly said in April that it demonstrated statistically significant efficacy results in a Phase 3 diabetes trial
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