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Induction of ferroptosis by HO-1 contributes to retinal degeneration in mice with defective clearance of all-trans-retinal

Piwecka, M., Rajewsky, N

J., Scott, C

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Continuous lipid accumulation impairs mitochondrial function and elevates ROS production, 64 leading to lipid peroxidation, DNA damage, and protein denaturation, collectively initiating oxidative stress, inflammatory signaling, and hepatocellular injury