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doi: 10.1007/s10068-015-0230-9 192

Activation of these receptors results in some cells (such as epithelial cells or cells of the innate immune system) producing IL-32, a cytokine that activates/differentiates monocytes into macrophages and induces the production of proinflammatory cytokines such as IL-1, IL-6, and TNF by activating NF-B in differentiated macrophages [231,232,233]

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NAPQI is a reactive metabolite formed by the action of cytochrome P450 on paracetamol (acetaminophen)