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Once contaminated by bacteria, their efficacy may decline at best, and severe infections may occur at worst

Off-label use is carried out solely at the doctor's clinical discretion and responsibility, with the patient's fully informed consent

Symptoms of a B12 Deficiency Initially, the symptoms of B12 deficiency can be difficult to notice

The fatigue likely stems from multiple factors working together

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This enrichment is crucial for maximizing the likelihood of detecting therapeutic effects and for avoiding the inclusion of patients unlikely to benefit from the intervention