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This dose is sub-therapeutic by design
Learn more: Cell by Cell Press Cell Press #neuroscience #neurology #durgdevelopment #clinicaltrials #diseasemodifyingtherapy #Alzheimer #Alzheimersdisease #dementia #cognitivedecline #tau #tauprotein #tauopathy #pathophysiology #neurodegeneration #neurodegenerativediseases #PET #PETimaging #neuroradiology #brainimaging #biomarkers #molecularimaging #tautherapy #ASO #anstisenseoligonucelotides #amyloid #immunization #ATN #immunotherapies #drugdiscovery #precisionmedicine #outcomes #outcomeresearch #trialdesign #adaptivedesign Figure: Lessons from anti-tau immunotherapies: Optimization of tau targeting and clinical trial design
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Posteriormente, se identific el GLP-1, en la dcada de 1980, que se sintetiza en las clulas L del intestino (leon distal y colon), en las clulas alfa del islote pancretico y en algunas reas neuronales, principalmente de la regin hipotalmica
Avoid self-administering or altering the dosage without medical guidance
Switching does not solve the problem and resets the titration clock
