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A novel HIF-2 targeted inhibitor suppresses hypoxia-induced breast cancer stemness via SOD2-mtROS-PDI/GPR78-UPR(ER) axis

At 2, 12, 18 and 24 hours media supernatants was analyzed

Consistent with the previously demonstrated ability of fluorescently-labelled GIP to access and activate the AP 5,7 , we found that acyl-GIP increased the total number of cells in the AP staining positive for cFos (a marker of neuronal activation) in control mice

For patients who cannot tolerate weekly injections, the oral form is a legitimate FDA-approved alternative