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2 Gut dysbiosis linked with obesity and type 2 diabetes The human gut accommodates a diverse community of enteric microflora, including Firmicutes and Bacteroidetes (up to 75% of total gut flora), which is also called a virtual organ, provides structural, metabolic, and protective benefits to intestinal epithelial cells (OHara and Shanahan, 2006
Iron uptake primarily occurs via transferrin receptor 1 (TfR1)-mediated endocytosis, where transferrin-bound iron (Fe 3+ ) is reduced to Fe 2+ by six-transmembrane epithelial antigen of the prostate 3 (STEAP3) and released into the cytosol (Kawabata, 2019)
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10.1002/glia.20526 419 SinghA.KukretiR.SasoL.KukretiS
