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DPP-IV modulates diverse cellular processes including survival, proliferation, and differentiation, and thereby enhances or diminishes tumorigenesis depending on the types or phases of tumors ( Initially, a register-based study from Taiwan suggested that the administration of DPP-4 inhibitors could be associated with an increased risk of TC (Tseng, 2016)

FIGURE 3 Changes in GDH levels have been observed in brain cells and other cell types with ageing, findings that may be associated with changes in CNS metabolism

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GUO: And in return for all of that investment, these companies, they get patents and exclusivities, these government-granted monopolies